Ø An increased Na+ excretion is accompanied by anion like Cl- Since NaCl is the major Sep 11, 2013 · thiazides
It blocks sodium, chloride and potassium from getting reabsorbed into the body, so those electrolytes stay in the tubules and move out through the urine
22 Loop Diuretics • Furosemide, torasemide, bumetanide: Are sulfonamide derivatives • ethacrynic acid is a phenoxyacetic acid derivative • Site of action: thick ascending limb of Henle • Mechanism: –
Figure 1
Mechanism of Action
Introduction Pharmacodynamics: Study of the biochemical and physiologic effects of drugs and their mechanisms of action
: MANNITOL) They are hydrophilic, that are Mechanism of action easily filtered through the glomerulus with little re- absorption and thus Increase
Lasix is a medication classified as a diuretic, or a water pill
1 of 31 Download Now Recommended Diuretics College of Pharmacy University of Sulaimani Antihypertensive drugs Dipesh Kakadiya Antianginal Drugs
DB14740
Diuretics are a medication used in the management and treatment of edematous and other non-edematous disease conditions
• However, Na+ balance is soon restored, even with continuing diuretic action, by compensatory homeostatic mechanisms of the body, albeit with a certain degree of persisting Na+ deficit and reduction in extracellular fluid volume
Diuretics • Describe the mechanisms of action of diuretics • Detail on the pharmacodynamic actions and pharmacokinetic aspects of diuretics • List ADRS
Pharmacodynamics • Loop diuretics inhibit the luminal Na+/K+/2Cl- transporter (NKCC2) in the TAL of Henle´s loop
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It can be taken intravenously or orally
Indications for the use of ARBs are similar to those for ACEIs
Spironolactone is a medication used in the management and treatment of hypertension and heart failure with some indications aside from cardiovascular disease
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It causes active pumping out of chloride from the cells lining the ascending limb of Loop of Henle and distal tubule by blocking the chloride
Dr Sevag Demirjian, director of Critical Care Nephrology at Cleveland Clinic, reviews the mechanism of action of furosemide (Lasix) in the kidney
IV: Immediate Onset Duration Oral: 8 hr; Inhalation: 3-6 hr; Modified-release preparation: 12 hr
Bicarbonate absorption by the proximal tubule is dependent on the activity of carbonic anhydrase (CA) which converts bicarbonate (HCO 3-) to CO 2 and H 2 O
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